Publications 2009 - 2010: Group Baccarini From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-a kinase activity Théodora Niault, Izabela Sobczak, Katrin Meissl, Gregory Weitsman, Daniela Piazzolla, Gabriele Maurer, Florian Kern, Karin Ehrenreiter, Matthias Hamerl, Ismail Moarefi, Thomas Leung, Oliviero Carugo, Tony Ng, and Manuela Baccarini [JCB featured article] Raf-1 addiction in Ras-induced skin carcinogenesis. Ehrenreiter K, Kern F, Velamoor V, Meissl K, Galabova-Kovacs G, Sibilia M, Baccarini M. Cancer Cell. 2009 Aug 4;16(2):149-60 [PubMed] A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal. Catalanotti F, Reyes G, Jesenberger V, Galabova-Kovacs G, de Matos Simoes R, Carugo O, Baccarini M. Nat Struct Mol Biol. 2009 Mar;16(3):294-303. [PubMed]   Group Decker Dendritic cells require STAT-1 phosphorylated at its transactivating domain for the induction of peptide-specific CTL. Pilz A, Kratky W, Stockinger S, Simma O, Kalinke U, Lingnau K, von Gabain A, Stoiber D, Sexl V, Kolbe T, Rülicke T, Müller M, Decker T. J Immunol. 2009 Aug 15;183(4):2286-93. [PubMed] Characterization of the interferon-producing cell in mice infected with Listeria monocytogenes. Stockinger S, Kastner R, Kernbauer E, Pilz A, Westermayer S, Reutterer B, Soulat D, Stengl G, Vogl C, Frenz T, Waibler Z, Taniguchi T, Rülicke T, Kalinke U, Müller M, Decker T. PLoS Pathog. 2009 Mar;5(3):e1000355. [PubMed] Identification of an indispensable role for tyrosine kinase 2 in CTL-mediated tumor surveillance. Simma O, Zebedin E, Neugebauer N, Schellack C, Pilz A, Chang-Rodriguez S, Lingnau K, Weisz E, Putz EM, Pickl WF, Felzmann T, Müller M, Decker T, Sexl V, Stoiber D. Cancer Res. 2009 Jan 1;69(1):203-11. [PubMed] Group Foisner Lamins: 'structure goes cycling'. Boban M, Braun J, Foisner R. Biochem Soc Trans. 2010 Feb;38(Pt 1):301-6 [PubMed] Lamina-Associated Polypeptide 2a Loss Impairs Heart Function and Stress Response in Mice. Gotic I, Leschnik M, Kolm U, Markovic M, Haubner BJ, Biadasiewicz K, Metzler B, Stewart CL, Foisner R. Circ Res. 2009 Nov 19. [PubMed] Lamin complexes in the nuclear interior control progenitor cell proliferation and tissue homeostasis. Naetar N, Foisner R. Cell Cycle. 2009 May 15;8(10):1488-93. [PubMed]   Group Kovarik Autophagy supports Candida glabrata survival during phagocytosis. Roetzer A, Gratz N, Kovarik P, Schüller C. Cell Microbiol. 2009 Oct 6. [PubMed] Tristetraprolin Is Required for Full Anti-Inflammatory Response of Murine Macrophages to IL-10. Schaljo B, Kratochvill F, Gratz N, Sadzak I, Sauer I, Hammer M, Vogl C, Strobl B, Müller M, Blackshear PJ, Poli V, Lang R, Murray PJ, Kovarik P.(2009) J Immunol. 2009 Jun 19. [PubMed] Group Meskiene Phosphatase Activities Analyzed by in vivo Expressions. Schweighofer, A., Ayatollahi, Z., and Meskiene, I. (2009) Methods Mol Biol 479, 247-260. [PubMed] Group Propst The cyclin dependent kinase inhibitor p21 is a crucial target for Histone deacetylase 1 as regulator of cellular proliferation. Zupkovitz G, Grausenburger R, Brunmeir R, Senese S, Tischler J, Jurkin J, Rembold M, Meunier D, Egger G, Lagger S, Chiocca S, Propst F, Weitzer G, Seiser C. Mol Cell Biol. (2009) [PubMed] Targeted inactivation of a developmentally regulated neural plectin isoform (plectin 1c) in mice leads to reduced motor nerve conduction velocity. Fuchs P, Zörer M, Reipert S, Rezniczek GA, Propst F, Walko G, Fischer I, Bauer J, Leschnik MW, Lüscher B, Thalhammer JG, Lassmann H, Wiche G. J Biol Chem. 2009 Sep 25;284(39):26502-9. [PubMed]   Group Seiser Epigenetic regulation of a murine retrotransposon by a dual histone modification mark. Brunmeir R, Lagger S, Simboeck E, Sawicka A, Egger G, Hagelkruys A, Zhang Y, Matthias P, Miller WJ, Seiser C. PLoS Genet. (2010) Apr 29;6(4):e1000927 The cyclin dependent kinase inhibitor p21 is a crucial target for Histone deacetylase 1 as regulator of cellular proliferation. Zupkovitz G, Grausenburger R, Brunmeir R, Senese S, Tischler J, Jurkin J, Rembold M, Meunier D, Egger G, Lagger S, Chiocca S, Propst F, Weitzer G, Seiser C. Mol Cell Biol. (2009) [PubMed] HDAC1/HDAC2- controlled embryonic development and cell differentiation. Brunmeir R*, Lagger S* and Seiser C (2009) Int. J. Developmental Biology 53:275-89 [PubMed] Group Warren Graham Warren: Gaining ground on the Golgi. Interview by Caitlin Sedwick. Warren G. J Cell Biol. 2010 Feb 22;188(4):448-9 [PubMed] Following the fate in vivo of COPI vesicles generated in vitro. Rutz C, Satoh A, Ronchi P, Brügger B, Warren G, Wieland FT. Traffic. 2009 Aug;10(8):994-1005. [PubMed] The bilobe structure of Trypanosoma brucei contains a MORN-repeat protein. Morriswood B, He CY, Sealey-Cardona M, Yelinek J, Pypaert M, Warren G. Mol Biochem Parasitol. 2009 Oct;167(2):95-103. [PubMed] Ultrastructural study of Golgi duplication in Trypanosoma brucei. Yelinek JT, He CY, Warren G. Traffic. 2009 Mar;10(3):300-6. [PubMed]   Group Wiche Plectin gene defects lead to various forms of epidermolysis bullosa simplex. Rezniczek GA, Walko G, Wiche G. Dermatol Clin. 2010 Jan;28(1):33-41 [PubMed]